Autophagy and Integrative Physiology in Aging

Autophagy is a cellular recycling program that degrades unwanted cytoplasmic contents within lysosomes. Autophagy occurs at basal levels in all cells and is induced during starvation and stress. Autophagy requires the de novo formation of a double-walled limiting membrane that sequesters cargo destined for degradation and seals upon itself to form an autophagosome. The delivery of the engulfed cargo to lysosomes by autophagosome-lysosome fusion results in cargo degradation. We demonstrated a role for autophagy in mobilization and degradation of intracellular lipid stores by a process we termed lipophagy, thus mapping autophagy to metabolic regulation. We have recently shown that lipophagy […]